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Dana-Farber's Targeted Protein Degradation Seminar Series
Join us for a seminar that's focusing on the most recent and exciting advances in targeted protein degradation. This event will feature a lecture by Alessio Ciulli (Dundee U.).

Nov 12, 2020 12:00 PM in Eastern Time (US and Canada)

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Alessio Ciulli, Ph.D.
Personal Chair of Chemical Structural Biology at the School of Life Sciences @University of Dundee
Dr Ciulli’s laboratory has made important contributions to selective chemical intervention on protein-protein interactions targets and to the development of proteolysis-targeting chimeric molecules (PROTACs) as a viable strategy for targeted protein degradation. Amongst his most significant discoveries are the fragment-based design of ligands for the E3 ligase von Hippel-Lindau (VHL), and their use to design one of the first VHL-based PROTACs: the BET degrader MZ1. Dr Ciulli’s Lab later illuminated fundamental insights into PROTACs’ mechanism of action, solving the first crystal structure of a PROTAC ternary complex. Dr. Ciulli is also the scientific founder of Amphista therapeutics, a company that develops new protein degradation platforms.